Immune System Diseases Centers and Programs

dna sequencing
DNA Sequencing Facility
Howell Lab
wheeler lab
Wheeler Lab
scientist in full body suit looks at glass
Small Animal Research Facility
zebra fish
Zebrafish Facility

Immune System Diseases Research Initiatives

Mast Cell and Mitochondrial Disruption by Triclosan and Related Antimicrobials

Principal Investigator

Co-PI's

Triclosan (TCS) is an antimicrobial banned by the USDA from soaps, but still used in other products such as toothpaste. Dr. Gosse has previously discovered that TCS inhibits the function of mitochondria and immune cell type mast cells. In this project, she plans to investigate the effects of TCS and TCS substitutes on plasma membrane potential, mast cell function, mitochondria and various cell types. This will likely generate data for a competitive NIH application.