Intravital Imaging Reveals Divergent Cytokine and Cellular Immune Responses to Candida albicans and Candida parapsilosis

LS Archambault, D Trzilova, S Gonia, C Gale, RT Wheeler

mBio 10 (3), e00266-19

Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

J Ho, X Yang, SA Nikou, N Kichik, A Donkin, NO Ponde, JP Richardson, …

Nature communications 10 (1), 2297

3 2019
Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

Y Wu, S Du, JL Johnson, HY Tung, CT Landers, Y Liu, BG Seman, …

Nature communications 10 (1), 58

15 2019
Studies into β-glucan recognition in fish suggests a key role for the C-type lectin pathway

J Petit, RT Wheeler, EV Carter, CAF Ferreira de Oliveira, M Forlenza, …

Frontiers in immunology 10, 280

1 2019
The Zebrafish as a model host for invasive fungal infections

EE Rosowski, BP Knox, LS Archambault, A Huttenlocher, NP Keller, …

Journal of Fungi 4 (4), 136

6 2018
Yeast and filaments have specialized, independent activities in a zebrafish model of Candida albicans infection

BG Seman, JL Moore, AK Scherer, BA Blair, S Manandhar, JM Jones, …

Infection and immunity 86 (10), e00415-18

7 2018
Epitope unmasking in vulvovaginal candidiasis is associated with hyphal growth and neutrophilic infiltration

E Pericolini, S Perito, A Castagnoli, E Gabrielli, A Mencacci, E Blasi, …

PloS one 13 (7), e0201436

5 2018
Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection

TM Tucey, J Verma, PF Harrison, SL Snelgrove, TL Lo, AK Scherer, …

Cell metabolism 27 (5), 988-1006. e7

26 2018
Dynamic fungal cell wall architecture in stress adaptation and immune evasion

A Hopke, AJP Brown, RA Hall, RT Wheeler

Trends in microbiology 26 (4), 284-295

29 2018
Candida albicans and Pseudomonas aeruginosa interact to enhance virulence of mucosal infection in transparent zebrafish

AC Bergeron, BG Seman, JH Hammond, LS Archambault, DA Hogan, …

Infection and immunity 85 (11), e00475-17

18 2017
Control of mucosal candidiasis in the zebrafish swim bladder depends on neutrophils that block filament invasion and drive extracellular-trap production

RL Gratacap, AK Scherer, BG Seman, RT Wheeler

Infection and immunity 85 (9), e00276-17

15 2017
In vitro detection of neutrophil traps and post-attack cell wall changes in Candida hyphae

A Hopke, RT Wheeler

Bio-protocol 7 (7)

4 2017
Candida parapsilosis protects premature intestinal epithelial cells from invasion and damage by Candida albicans

S Gonia, L Archambault, M Shevik, M Altendahl, E Fellows, JM Bliss, …

Frontiers in pediatrics 5, 54

4 2017
Polyclonal anti-Candida antibody improves phagocytosis and overall outcome in zebrafish model of disseminated candidiasis

AC Bergeron, SE Barker, KM Brothers, BC Prasad, RT Wheeler

Developmental & Comparative Immunology 68, 69-78

4 2017
β-(1, 3)-glucan unmasking in some Candida albicans mutants correlates with increases in cell wall surface roughness and decreases in cell wall elasticity

S Hasim, DP Allison, ST Retterer, A Hopke, RT Wheeler, MJ Doktycz, …

Infection and immunity 85 (1), e00601-16

16 2017
Hsf1 and Hsp90 orchestrate temperature-dependent global transcriptional remodelling and chromatin architecture in Candida albicans

MD Leach, RA Farrer, K Tan, Z Miao, LA Walker, CA Cuomo, RT Wheeler, …

Nature communications 7, 11704

51 2016
Phenotypic plasticity regulates Candida albicans interactions and virulence in the vertebrate host

EM Mallick, AC Bergeron, SK Jones Jr, ZR Newman, KM Brothers, …

Frontiers in microbiology 7, 780

17 2016
Neutrophil attack triggers extracellular trap-dependent Candida cell wall remodeling and altered immune recognition

A Hopke, N Nicke, EE Hidu, G Degani, L Popolo, RT Wheeler

PLoS pathogens 12 (5), e1005644

61 2016
Candidalysin is a fungal peptide toxin critical for mucosal infection

DL Moyes, D Wilson, JP Richardson, S Mogavero, SX Tang, J Wernecke, …

Nature 532 (7597), 64

268 2016
A zebrafish larval model reveals early tissue-specific innate immune responses to Mucor circinelloides

K Voelz, RL Gratacap, RT Wheeler

Disease models & mechanisms 8 (11), 1375-1388

33 2015
Fungal pathogens: survival and replication within macrophages

AS Gilbert, RT Wheeler, RC May

Cold Spring Harbor perspectives in medicine 5 (7), a019661

41 2015
Modeling mucosal candidiasis in larval zebrafish by swimbladder injection

RL Gratacap, AC Bergeron, RT Wheeler

JoVE (Journal of Visualized Experiments), e52182

16 2014
Masking of β (1-3)-glucan in the cell wall of Candida albicans from detection by innate immune cells depends on phosphatidylserine

SE Davis, A Hopke, SC Minkin, AE Montedonico, RT Wheeler, …

Infection and immunity 82 (10), 4405-4413

37 2014
Utilization of zebrafish for intravital study of eukaryotic pathogen–host interactions

RL Gratacap, RT Wheeler

Developmental & Comparative Immunology 46 (1), 108-115

33 2014
The complex roles of NADPH oxidases in fungal infection

D Hogan, RT Wheeler

Cellular microbiology 16 (8), 1156-1167

27 2014
CX3CR1-dependent renal macrophage survival promotes Candida control and host survival

MS Lionakis, M Swamydas, BG Fischer, TS Plantinga, MD Johnson, …

The Journal of clinical investigation 123 (12), 5035-5051

138 2013
NADPH oxidase-driven phagocyte recruitment controls Candida albicans filamentous growth and prevents mortality

KM Brothers, RL Gratacap, SE Barker, ZR Newman, A Norum, …

PLoS pathogens 9 (10), e1003634

77 2013
Mucosal candidiasis elicits NF-κB activation, proinflammatory gene expression and localized neutrophilia in zebrafish

RL Gratacap, JF Rawls, RT Wheeler

Disease models & mechanisms 6 (5), 1260-1270

55 2013
Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1

MJ Marakalala, S Vautier, J Potrykus, LA Walker, KM Shepardson, …

PLoS pathogens 9 (4), e1003315

139 2013
Candida albicans induces arginine biosynthetic genes in response to host-derived reactive oxygen species

C Jiménez-López, JR Collette, KM Brothers, KM Shepardson, RA Cramer, …

Eukaryotic cell 12 (1), 91-100

47 2013
Non-invasive imaging of disseminated candidiasis in zebrafish larvae

KM Brothers, RT Wheeler

JoVE (Journal of Visualized Experiments), e4051

27 2012
Zebrafish: a see-through host and a fluorescent toolbox to probe host–pathogen interaction

DM Tobin, RC May, RT Wheeler

PLoS pathogens 8 (1), e1002349

84 2012
Live imaging of disseminated candidiasis in zebrafish reveals role of phagocyte oxidase in limiting filamentous growth

KM Brothers, ZR Newman, RT Wheeler

Eukaryotic cell 10 (7), 932-944

119 2011
Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p

JF Moxley, MC Jewett, MR Antoniewicz, SG Villas-Boas, H Alper, …

Proceedings of the National Academy of Sciences 106 (16), 6477-6482

164 2009
Dynamic, morphotype-specific Candida albicans β-glucan exposure during infection and drug treatment

RT Wheeler, D Kombe, SD Agarwala, GR Fink

PLoS pathogens 4 (12), e1000227

244 2008
Drug Induced Exposure Of The Fungal Pro-Inflammatory Molecule Beta-Glucan

RT Wheeler, GR Fink

US Patent App. 12/048,559

2 2008
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

JB Johnnidis, MH Harris, RT Wheeler, S Stehling-Sun, MH Lam, O Kirak, …

Nature 451 (7182), 1125