Julie Gosse

Education

Postdoctoral training (2005-2007) Dartmouth Medical School
Ph.D. (2005) Cornell University

Location:  Hitchner Hall

Mailing Address:  5735 Hitchner Hall Orono, ME  04469-5706

Teaching

  • Biochemistry for Molecular and Biomedical Sciences, BMB 360 (Spring)
  • Physical Biochemistry, BMB 467 (Fall)
  • BMB 597, Special Topics (Graduate Physical Biochemistry) (Fall)
  • Undergraduate and Graduate Seminar in Biochemistry, BMB 582 (Fall, Spring)
  • Biochemistry, Microbiology, and Molecular Biology Senior Research Capstone, BMB 491  (Fall, Spring, Summer)
  • Independent Research Study, BMB 497 (Fall, Spring, Summer)
  • Graduate Research, BMB 699 (Fall, Spring, Summer)
  • Honors Directed Study/Honors Thesis, HON 498/499 (Fall, Spring, Summer)

Research Interests

Biochemical, molecular, biophysical, and cellular toxicology.  Effects of toxicants on signal transduction pathways and mitochondria.

Peer-Reviewed Publications

  1. Molecular Mechanisms Underlying Antimicrobial Agent Triclosan’s Inhibition of Mast Cell Signaling: Roles of Protein Kinase C and Phospholipase D; Juyoung K. Shim, Molly A. Caron, Lisa M. Weatherly, Logan B. Gerchman, Suraj Sangroula, Siham Hattab, Alan Y. Baez, Talya J. Briana, Julie A. Gosse; submitted
  2. Maternal responsivity and oxytocin in opioid dependent mothers; Katrina M. Daigle, Ella J. Sulinski, Juyoung Shim, Nicole A. Heller, William Lindblad, Julie A. Gosse, Marie J. Hayes; submitted
  3. Searching for Tryptase in the RBL-2H3 Mast Cell Model:  Preparation for Comparative Mast Cell Toxicology Studies with Zebrafish; Juyoung K. Shim, Rachel H. Kennedy, Lisa M. Weatherly, Andrew V. Abovian, Hina N. Hashmi, Atefeh Rajaei, Julie A. Gosse; in press at Journal of Applied Toxicology, 2018
  4. “Antimicrobial Agent Triclosan Disrupts Mitochondrial Structure, Revealed by Super-resolution Microscopy, and Inhibits Mast Cell Signaling via Calcium Modulation,” Lisa M.Weatherly, Andrew J. Nelson, Juyoung Shim, Abigail M. Riitano, Erik D. Gerson, Andrew J. Hart, Jaime de Juan-Sanz, Timothy A. Ryan, Roger Sher, Samuel T. Hess, Julie A. Gosse, 2018, Toxicol Appl Pharmacol.; 349:39-54. doi: 10.1016/j.taap.2018.04.005.
  5. “Elevated nitrate alters the metabolic activity of embryonic zebrafish,” Conlin SM, Tudor MS, Shim J, Gosse JA, Neilson A, Hamlin HJ, 2017, Environ Pollut.; 235:180-185. doi: 10.1016/j.envpol.2017.12.069.
  6. “Triclosan Exposure, Transformation, and Human Health Effects,” Lisa M. Weatherly and Julie A. Gosse, 2017, J Toxicol Environ Health B Crit Rev.; 20(8):447-469. doi: 10.1080/10937404.2017.1399306.
  7. “Triclosan is a Mitochondrial Uncoupler in Live Zebrafish,” Juyoung Shim, Lisa M. Weatherly, Richard H. Luc, Maxwell T. Dorman, Andy Neilson, Ryan Ng, Carol H. Kim, Paul J. Millard, Julie A. Gosse, 2016,  Journal of Applied Toxicology, doi: 10.1002/jat.3311.
  8. “Arsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events,” Juyoung Shim*, Rachel H. Kennedy*, Lisa M. Weatherly, Lee M. Hutchinson, Jonathan H. Pelletier, Hina N. Hashmi, Kayla Blais, Alejandro Velez, Julie A. Gosse (*contributed equally), 2016, Journal of Applied Toxicology, doi: 10.1002/jat.3300.
  9. “Antimicrobial Agent Triclosan is a Proton Ionophore Uncoupler of Mitochondria in Living Rat and Human Mast Cells and in Primary Human Keratinocytes,” Lisa M. Weatherly, Juyoung Shim, Hina N. Hashmi, Rachel H. Kennedy, Samuel T. Hess, and Julie A. Gosse, 2015, Journal of Applied Toxicology, doi: 10.1002/jat.3209. [Epub ahead of print]
  10. “Visualizing the molecular timing of a physiological decision at the nanoscale,” Samuel T. Hess* and Julie A. Gosse*, Biophysical Journal, 2013, vol. 105, pp. 2617-8. *co-corresponding authors.
  11. “Monomethylated Trivalent Arsenic Species Disrupt Steroid Receptor Interactions with their DNA Response Elements at Non-cytotoxic Cellular Concentrations,” Julie A. Gosse, Vivien F. Taylor, Brian P. Jackson, Joshua W. Hamilton, and Jack E. Bodwell, Journal of Applied Toxicology, 2013, doi: 10.1002/jat.2898
  12. “Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study,” Dennis Liang Fei, Devin C. Koestler, Zhigang Li, Camilla Giambelli, Avencia Sanchez-Mejias, Julie A. Gosse, Carmen J. Marsit, Margaret R. Karagas, and David J. Robbins, Environmental Health, 2013, vol. 12, p. 58.
  13. “A Microplate Assay to Assess Chemical Effects of RBL-2H3 Mast Cell Degranulation:  Effects of Triclosan Without Use of an Organic Solvent,” Lisa M. Weatherly, Rachel H. Kennedy, Juyoung Shim, and Julie A. Gosse*, Journal of Visualized Experiments, 2013, vol. 81, e50671, doi:10.3791/50671. *corresponding author.
  14. “Actin Mediates the Nanoscale Membrane Organization of the Clustered Membrane Protein Influenza Hemagglutinin,” Manasa V. Gudheti, Nikki M. Curthoys, Travis J. Gould, Dahan Kim, Mudalige S. Gunewardene, Kristin A. Gabor, Julie A. Gosse, Carol H. Kim, Joshua Zimmerberg, and Samuel T. Hess, Biophysical Journal, 2013, vol. 104, pp. 2182-2192.
  15. Estrogen mimetic 4-tert-octylphenol enhances IgE-mediated degranulation of RBL-2H3 mast cells, Rachel H. Kennedy, Jonathan H. Pelletier, Emily J. Tupper, Lee M. Hutchinson, and Julie A. Gosse*, Journal of Toxicology and Environmental Health, Part A, vol. 75, 2012, pp. 1451-1455.  *corresponding author.
  16. Antibacterial agent triclosan suppresses RBL-2H3 mast cell function, Rachel K. Palmer, Lee M. Hutchinson, Benjamin T. Burpee, Emily J. Tupper, Jonathan H. Pelletier, Zsolt Kormendy, Alex R. Hopke, Ethan T. Malay, Brieana L. Evans, Alejandro Velez, Julie A. Gosse*, Toxicology and Applied Pharmacology, vol. 258, 2012, pp. 99-108. *corresponding author.
  17. Inorganic Arsenite Inhibits IgE Receptor-Mediated Degranulation of Mast Cells, Lee M. Hutchinson, Benett M. Trinh, Rachel K. Palmer, Christopher A. Preziosi, Jonathan H. Pelletier, Hannah M. Nelson, Julie A. Gosse*, Journal of Applied Toxicology, vol. 31, 2011, pp. 231-241.  *corresponding author.
  18. Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors, Dennis Liang Fei, Hua Li, Courtney D. Kozul, Kendall E. Black, Samer Singh, Julie A. Gosse, James DiRenzo, Kathleen A. Martin, Baolin Wang, Joshua W. Hamilton, Margaret R. Karagas, and David J. Robbins, Cancer Research, vol. 70, 2010, pp. 1981-8.
  19. Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung, Courtney D. Kozul, Thomas H. Hampton, Jennifer C. Davey, Julie A. Gosse, Athena P. Nomikos, Phillip L. Eisenhauer, Daniel J. Weiss, Jessica E. Thorpe, Michael A. Ihnat, Joshua W. Hamilton, Environmental Health Perspectives, vol. 117, 2009, pp. 1108-1115
  20. A new approach to analysis and interpretation of toxicogenomic gene expression data and its importance in examining biological responses to low, environmentally-relevant doses of toxicants, Julie A. Gosse, Thomas H. Hampton, Jennifer C. Davey, Joshua W. Hamilton, in book entitled Toxicogenomics: A powerful tool for toxicity assessment, edited by Saura C. Sahu, John Wiley & Sons Ltd., Oct. 2008, pp. 27-57.
  21. Nanoscale imaging of molecular positions and anisotropies, Travis J. Gould, Mudalige S. Gunewardene, Manasa V. Gudheti, Vladislav V. Verkhusha, Shu-Rong Yin, Julie A. Gosse, Samuel T. Hess, Nature Methods, vol. 5, 2008, pp. 1027-30.
  22. Laboratory Diet Profoundly Alters Gene Expression and Confounds Genomic Analysis in Mouse Liver and Lung, Courtney D. Kozul, Athena P. Nomikos, Thomas H. Hampton, Linda A. Warnke, Julie A. Gosse, Jennifer C. Davey, Jessica E. Thorpe, Brian P. Jackson, Michael A. Ihnat, Joshua W. Hamilton, Chemico-Biological Interactions, vol. 173, 2008, p. 129-140.
  23. Arsenic as an endocrine disruptor: Effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture, Jennifer C. Davey, Jack E. Bodwell, Julie A. Gosse, Joshua W. Hamilton, Toxicological Sciences, vol. 98, 2007, pp. 75-86.
  24. Arsenic disruption of steriod receptor gene activation: Complex dose-response effects are shared by several steroid receptors, Jack E. Bodwell, Julie A. Gosse, Athena P. Nomikos, Joshua W. Hamilton, Chemical Research in Toxicology, vol. 19, issue 12, 2006, pp. 1619-29.
  25. Transmembrane sequences are determinants of immunoreceptor signaling, Julie A. Gosse, Alice Wagenknecht-Wiesner, David Holowka, Barbara Baird, The Journal of Immunology, vol. 175, 2005, pp. 2123-31.
  26. Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells, Daniel R. Larson*, Julie A. Gosse*, David A. Holowka, Barbara A. Baird, Watt W. Webb (*First two authors contributed equally to this work), The Journal of Cell Biology, vol. 171, 2005, pp. 527-36.
  27. Lipid segregation and IgE receptor signaling: A decade of progress, David Holowka, Julie A. Gosse, Adam T. Hammond, Xuemei Han, Prabuddha Sengupta, Norah L. Smith, Alice Wagenknecht-Wiesner, Min Wu, Ryan M. Young, Barbara Baird, Biochimica et Biophysica Acta-Molecular Cell Research, vol. 1746, 2005, pp. 252-9.