Kelley Lab Publishes Paper on Link Between Chromatin Modification State and Nuclear Transport
In collaboration with the Paschal Lab at the University of Virginia, the Kelley Lab has published a new paper in Aging Cell. Kelley Lab members William Simke and Isaac Johnson generated yeast missing a key histone methyltransferase and examined the ability of the cell to properly localize Ran. Ran is the main regulator of nucleocytoplasmic transport, and proper regulation of Ran results in its accumulation in the nucleus. Corroborating the Paschal lab findings using pharmacological inhibitors, we found that proper Ran localization was dependent upon the activity of histone methyl transferase.
A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling. Dworak N, Makosa D, Chatterjee M, Jividen K, Yang CS, Snow C, Simke WC, Johnson IG, Kelley JB, Paschal BM. Aging Cell. 2018 Dec 19:e12851. doi: 10.1111/acel.12851. PMID: 30565836