Spaulding publishes dissertation research in Science

Emily Spaulding, 2019 Graduate School of Biomedical Science and Engineering (GSBSE) Ph.D. in biomedical sciences, has published the culmination of her dissertation work in two papers in the Sept. 3 issue of Science. Emily’s work showed that mutations that cause a form of inherited peripheral neuropathy (Charcot-Marie-Tooth disease type 2D) lead to defects in proteins synthesis and activation of the integrated stress response specifically in motor and sensory neurons. Inhibiting the integrated stress response resulted in a much milder neuropathy phenotype in mouse models of CMT2D, identifying this pathway as a highly effective therapeutic target for this disease. The two papers are online: and