Spatiotemporally Tunable Biomaterials
Cells respond to numerous mechanical, topological, and chemical cues from their surroundings or extracellular matrix (ECM). Synthetic hydrogels are an excellent synthetic mimic that can be tuned to study how individual parameters affect cell fate, control cellular regeneration, and serve as scaffolds for biological growth.
We create new macromonomers from polysaccharides to synthesize biomaterials using orthogonal chemistry to independently pattern mechanical properties and chemicals. Additionally, we also incorporate new chemical and structure cues into biomaterials to control stem cell differentiation.
We are currently researching:
Composite cellulose derived biomaterials for human mesenchymal stem cell culture.
Hydrogels that incorporate glycans as a biological cue.
New hydrogel formulations for bioinks.
Selected Publications