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Molecular & Biomedical Sciences


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Faculty - Julie Gosse

Phone: (207) 581-4833
Email/web: Send an Email

Education

Ph.D. (2005) Cornell University

Postdoctoral training (2005-2007) Dartmouth Medical School

Teaching

Biochemistry Lecture, BMB 322 (Spring)

Physical Biochemistry, BMB 467 (Fall)

Toxicant Effects on Signal Transduction Pathways, BMB 597 (Graduate course, Fall)

Undergraduate Seminar in Biochemistry, BMB 582 (Fall, Spring)

Biochemistry, Microbiology, and Molecular Biology Senior Research Capstone, BMB 491  (Fall, Spring, Summer)

Independent Research Study, BMB 497 (Fall, Spring, Summer)

Graduate Research, BMB 699 (Fall, Spring, Summer)

Honors Directed Study/Honors Thesis, HON 498/499 (Fall, Spring, Summer)

Research interests

Biochemical, molecular, and cellular toxicology to aid in human environmental health risk assessment.  Effects of toxicants on signal transduction pathways.

Arsenic.  Exposure to even low doses of arsenic has been linked to several types of cancer, cardiovascular disease, and reproductive and developmental problems.  Surprisingly, about 25 million people in the U.S., plus many more people in other parts of the world, are consuming excess arsenic via their drinking water.   In particular, about 150,000 people in Maine are drinking water containing arsenic in excess of 10 ppb, which is the federal drinking water standard, because they obtain their water from unregulated, contaminated, private wells.  In addition to natural groundwater sources, arsenic contamination exists at Superfund waste sites, in soil of old orchards (onto which were once applied arsenical pesticides), at mining and industrial sites, from pressure-treated lumber, and in various types of food.

Endocrine disruption, allergy, and carcinogenesis caused by arsenic and other environmental toxicants. Arsenic and other toxic metals are endocrine disruptors, although the molecular mechanisms are not fully understood.  Also, various toxicants can exacerbate mast cell degranulation and potentiate the allergic response.  Understanding the mechanism by which a toxicant causes endocrine disruption or allergy can aid in science-based regulation of contaminants in order to be protective of human health and also can lend insights into the basic molecular mechanisms underlying endocrine and allergic signal transduction.  Our laboratory is also investigating molecular processes, in addition to endocrine disruption, by which arsenic promotes carcinogenesis.  We use a variety of biochemical, molecular, and cellular tools to determine the mechanisms by which arsenic and other environmental toxicants cause endocrine disruption, allergy, and carcinogenesis.

Publications

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Contact Information

Molecular & Biomedical Sciences
5735 Hitchner Hall
Orono, Maine 04469-5735
Phone: (207) 581-2810 | Fax: (207) 581-2801E-mail: Chair: gundersn@maine.edu
The University of Maine
Orono, Maine 04469
207.581.1110
A Member of the University of Maine System