Faculty - Julie Gosse
Phone: (207) 581-4833
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Ph.D. (2005) Cornell University
Postdoctoral training (2005-2007) Dartmouth Medical School
Biochemistry Lecture, BMB 322 (Spring)
Physical Biochemistry, BMB 467 (Fall)
Toxicant Effects on Signal Transduction Pathways, BMB 597 (Graduate course)
Undergraduate and Graduate Seminar in Biochemistry, BMB 582 (Fall, Spring)
Biochemistry, Microbiology, and Molecular Biology Senior Research Capstone, BMB 491 (Fall, Spring, Summer)
Independent Research Study, BMB 497 (Fall, Spring, Summer)
Graduate Research, BMB 699 (Fall, Spring, Summer)
Honors Directed Study/Honors Thesis, HON 498/499 (Fall, Spring, Summer)
Biochemical, molecular, and cellular toxicology to aid in human environmental health risk assessment. Effects of toxicants on signal transduction pathways.
Arsenic. Exposure to even low doses of arsenic has been linked to several types of cancer, cardiovascular disease, and reproductive and developmental problems. Surprisingly, about 25 million people in the U.S., plus many more people in other parts of the world, are consuming excess arsenic via their drinking water. In particular, about 150,000 people in Maine are drinking water containing arsenic in excess of 10 ppb, which is the federal drinking water standard, because they obtain their water from unregulated, contaminated, private wells. In addition to natural groundwater sources, arsenic contamination exists at Superfund waste sites, in soil of old orchards (onto which were once applied arsenical pesticides), at mining and industrial sites, from pressure-treated lumber, and in various types of food.
Endocrine disruption, allergy, and carcinogenesis caused by arsenic and other environmental toxicants. Arsenic and other toxic metals are endocrine disruptors, although the molecular mechanisms are not fully understood. Also, various toxicants can exacerbate mast cell degranulation and potentiate the allergic response. Understanding the mechanism by which a toxicant causes endocrine disruption or allergy can aid in science-based regulation of contaminants in order to be protective of human health and also can lend insights into the basic molecular mechanisms underlying endocrine and allergic signal transduction. Our laboratory is also investigating molecular processes, in addition to endocrine disruption, by which arsenic promotes carcinogenesis. We use a variety of biochemical, molecular, and cellular tools to determine the mechanisms by which arsenic and other environmental toxicants cause endocrine disruption, allergy, and carcinogenesis.
- “Triclosan is a Mitochondrial Uncoupler in Live Zebrafish,” Juyoung Shim, Lisa M. Weatherly, Richard H. Luc, Maxwell T. Dorman, Andy Neilson, Ryan Ng, Carol H. Kim, Paul J. Millard, Julie A. Gosse, 2016, Journal of Applied Toxicology, doi: 10.1002/jat.3311.
- “Arsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events,” Juyoung Shim*, Rachel H. Kennedy*, Lisa M. Weatherly, Lee M. Hutchinson, Jonathan H. Pelletier, Hina N. Hashmi, Kayla Blais, Alejandro Velez, Julie A. Gosse (*contributed equally), 2016, Journal of Applied Toxicology, doi: 10.1002/jat.3300.
- “Antimicrobial Agent Triclosan is a Proton Ionophore Uncoupler of Mitochondria in Living Rat and Human Mast Cells and in Primary Human Keratinocytes,” Lisa M. Weatherly, Juyoung Shim, Hina N. Hashmi, Rachel H. Kennedy, Samuel T. Hess, and Julie A. Gosse, 2015, Journal of Applied Toxicology, doi: 10.1002/jat.3209. [Epub ahead of print]
- “Visualizing the molecular timing of a physiological decision at the nanoscale,” Samuel T. Hess* and Julie A. Gosse*, Biophysical Journal, 2013, vol. 105, pp. 2617-8. *co-corresponding authors.
- “Monomethylated Trivalent Arsenic Species Disrupt Steroid Receptor Interactions with their DNA Response Elements at Non-cytotoxic Cellular Concentrations,” Julie A. Gosse, Vivien F. Taylor, Brian P. Jackson, Joshua W. Hamilton, and Jack E. Bodwell, Journal of Applied Toxicology, 2013, doi: 10.1002/jat.2898
- “Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study,” Dennis Liang Fei, Devin C. Koestler, Zhigang Li, Camilla Giambelli, Avencia Sanchez-Mejias, Julie A. Gosse, Carmen J. Marsit, Margaret R. Karagas, and David J. Robbins, Environmental Health, 2013, vol. 12, p. 58.
- “A Microplate Assay to Assess Chemical Effects of RBL-2H3 Mast Cell Degranulation: Effects of Triclosan Without Use of an Organic Solvent,” Lisa M. Weatherly, Rachel H. Kennedy, Juyoung Shim, and Julie A. Gosse*, Journal of Visualized Experiments, 2013, vol. 81, e50671, doi:10.3791/50671. *corresponding author.
- “Actin Mediates the Nanoscale Membrane Organization of the Clustered Membrane Protein Influenza Hemagglutinin,” Manasa V. Gudheti, Nikki M. Curthoys, Travis J. Gould, Dahan Kim, Mudalige S. Gunewardene, Kristin A. Gabor, Julie A. Gosse, Carol H. Kim, Joshua Zimmerberg, and Samuel T. Hess, Biophysical Journal, 2013, vol. 104, pp. 2182-2192.
- Estrogen mimetic 4-tert-octylphenol enhances IgE-mediated degranulation of RBL-2H3 mast cells, Rachel H. Kennedy, Jonathan H. Pelletier, Emily J. Tupper, Lee M. Hutchinson, and Julie A. Gosse*, Journal of Toxicology and Environmental Health, Part A, vol. 75, 2012, pp. 1451-1455. *corresponding author.
- Antibacterial agent triclosan suppresses RBL-2H3 mast cell function, Rachel K. Palmer, Lee M. Hutchinson, Benjamin T. Burpee, Emily J. Tupper, Jonathan H. Pelletier, Zsolt Kormendy, Alex R. Hopke, Ethan T. Malay, Brieana L. Evans, Alejandro Velez, Julie A. Gosse*, Toxicology and Applied Pharmacology, vol. 258, 2012, pp. 99-108. *corresponding author.
- Inorganic Arsenite Inhibits IgE Receptor-Mediated Degranulation of Mast Cells, Lee M. Hutchinson, Benett M. Trinh, Rachel K. Palmer, Christopher A. Preziosi, Jonathan H. Pelletier, Hannah M. Nelson, Julie A. Gosse*, Journal of Applied Toxicology, vol. 31, 2011, pp. 231-241. *corresponding author.
- Activation of Hedgehog Signaling by the Environmental Toxicant Arsenic May Contribute to the Etiology of Arsenic-Induced Tumors, Dennis Liang Fei, Hua Li, Courtney D. Kozul, Kendall E. Black, Samer Singh, Julie A. Gosse, James DiRenzo, Kathleen A. Martin, Baolin Wang, Joshua W. Hamilton, Margaret R. Karagas, and David J. Robbins, Cancer Research, vol. 70, 2010, pp. 1981-8.
- Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung, Courtney D. Kozul, Thomas H. Hampton, Jennifer C. Davey, Julie A. Gosse, Athena P. Nomikos, Phillip L. Eisenhauer, Daniel J. Weiss, Jessica E. Thorpe, Michael A. Ihnat, Joshua W. Hamilton, Environmental Health Perspectives, vol. 117, 2009, pp. 1108-1115
- A new approach to analysis and interpretation of toxicogenomic gene expression data and its importance in examining biological responses to low, environmentally-relevant doses of toxicants, Julie A. Gosse, Thomas H. Hampton, Jennifer C. Davey, Joshua W. Hamilton, in book entitled Toxicogenomics: A powerful tool for toxicity assessment, edited by Saura C. Sahu, John Wiley & Sons Ltd., Oct. 2008, pp. 27-57.
- Nanoscale imaging of molecular positions and anisotropies, Travis J. Gould, Mudalige S. Gunewardene, Manasa V. Gudheti, Vladislav V. Verkhusha, Shu-Rong Yin, Julie A. Gosse, Samuel T. Hess, Nature Methods, vol. 5, 2008, pp. 1027-30.
- Laboratory Diet Profoundly Alters Gene Expression and Confounds Genomic Analysis in Mouse Liver and Lung, Courtney D. Kozul, Athena P. Nomikos, Thomas H. Hampton, Linda A. Warnke, Julie A. Gosse, Jennifer C. Davey, Jessica E. Thorpe, Brian P. Jackson, Michael A. Ihnat, Joshua W. Hamilton, Chemico-Biological Interactions, vol. 173, 2008, p. 129-140.
- Arsenic as an endocrine disruptor: Effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture, Jennifer C. Davey, Jack E. Bodwell, Julie A. Gosse, Joshua W. Hamilton, Toxicological Sciences, vol. 98, 2007, pp. 75-86.
- Arsenic disruption of steriod receptor gene activation: Complex dose-response effects are shared by several steroid receptors, Jack E. Bodwell, Julie A. Gosse, Athena P. Nomikos, Joshua W. Hamilton, Chemical Research in Toxicology, vol. 19, issue 12, 2006, pp. 1619-29.
- Transmembrane sequences are determinants of immunoreceptor signaling, Julie A. Gosse, Alice Wagenknecht-Wiesner, David Holowka, Barbara Baird, The Journal of Immunology, vol. 175, 2005, pp. 2123-31.
- Temporally resolved interactions between antigen-stimulated IgE receptors and Lyn kinase on living cells, Daniel R. Larson*, Julie A. Gosse*, David A. Holowka, Barbara A. Baird, Watt W. Webb (*First two authors contributed equally to this work), The Journal of Cell Biology, vol. 171, 2005, pp. 527-36.
- Lipid segregation and IgE receptor signaling: A decade of progress, David Holowka, Julie A. Gosse, Adam T. Hammond, Xuemei Han, Prabuddha Sengupta, Norah L. Smith, Alice Wagenknecht-Wiesner, Min Wu, Ryan M. Young, Barbara Baird, Biochimica et Biophysica Acta-Molecular Cell Research, vol. 1746, 2005, pp. 252-9.