Emily Spaulding, 2019 Graduate School of Biomedical Science and Engineering (GSBSE) Ph.D. in biomedical sciences, has published the culmination of her dissertation work in two papers in the Sept. 3 issue of Science. Emily’s work showed that mutations that cause a form of inherited peripheral neuropathy (Charcot-Marie-Tooth disease type 2D) lead to defects in proteins synthesis and activation of the integrated stress response specifically in motor and sensory neurons. Inhibiting the integrated stress response resulted in a much milder neuropathy phenotype in mouse models of CMT2D, identifying this pathway as a highly effective therapeutic target for this disease. The two papers are online: science.org/doi/10.1126/science.abb3414 and science.org/doi/10.1126/science.abb3356.
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