Speaker: Clifford J. Rosen, MD, Professor of Medicine Tufts University School of Medicine, Principal Investigator of the NNE-CTR.
About the seminar: Vitamin D supplementation is the most commonly administered treatment in clinical practice in the US and vitamin D measurement testing is rampant. I will discuss the physiology of Vitamin D, the rationale for treatment, and the evidence that supposedly backs that up.
About the speaker: Dr. Rosen oversees the Rosen Musculoskeletal Laboratory and the Physiology Core at the MaineHealth Institute for Research (formerly MMCRI) and is a board certified endocrinologist. He has more than twenty-five years of continuous NIH funding as a PI, first at The Jackson Laboratory and subsequently at MMCRI. In the last ten years the Rosen laboratory has been studying mesenchymal stem cell fate with particular reference to the switch between pre-adipocytes and pre-osteoblasts, and with a focus on the bioenergetic programs of those progenitors. Dr. Rosen is the multiple PI on a U19 from NIA in collaboration with M. Zaidi to study the effects of FSH on adipose tissue particularly during aging. This grant includes Mt. Sinai, Maine, UT Southwestern and UCSF. Dr. Rosen is also a multiple PI on an NIH funded clinical trial to study whether beta blockers can prevent bone loss in post-menopausal women. He is the Director of the Physiology Core of the P20 COBRE in Mesenchymal and Neural Regulation of Metabolic Networks (NIGMS) and his lab has studied osteoblast progenitor mitochondrial respiration as well being involved in pre-clinical studies of changes in the microbiome with age, diet, and location. In the former role, Dr. Rosen is a multi-PI on an RO1 from NIAMS that examines how progenitor fate can be tied to expression of Zfp467 and its impact on the bioenergetic profile of adipocytes and osteoblasts. Importantly, Dr. Rosen is the contact Principal Investigator of the Northern New England Clinical and Translational Research Network (NNE-CTR), a U54 program grant from NIGMS that promotes clinical translation and clinical trials interwoven with basic science investigations. Building on his work with the NNE-CTR, Dr. Rosen is now serving as one of two Principal Investigators for a consortium of eleven CTR programs, ISCORE, in RECOVER. Dr. Rosen also chairs the Steering Committee of ISCORE, and coordinates activities between the national consortium and the CTR network.
Dr. Rosen is the past president of the American Society of Bone and Mineral Research and currently a council member of the National Advisory Committee on Aging (NIA). He previously served a four-year term on the NIAMS council and the Board of the Endocrine Society. Dr. Rosen is chair of the governance committee for the CTR N3C network that is collecting data on Covid from around the country. He has been an Associate Editor at New England Journal of Medicine for almost 7 years, and a Senior Editor at eLife. Biology. Dr. Rosen has published 571 peer-reviewed publications in Journals such as Nature, Nature Medicine, Cell, Cell Metabolism, PNAS, New England Journal, Journal of Clinical Investigation and Lancet. In this proposal, Dr. Rosen will work closely with Dr. Kathleen Becker in her R16 application, particularly with a focus on skeletal biology and the role of the saphenous nerve in regulating bone turnover. Read more
This event is free, but registration is required