Kelley Lab at UMaine

Publications

• A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling.
  Dworak N, Makosa D, Chatterjee M, Jividen K, Yang CS, Snow C, Simke WC, Johnson IG, Kelley JB, Paschal BM.
  Aging Cell. 2018 Dec 19:e12851. doi: 10.1111/acel.12851. [Epub ahead of print]
  PMID: 30565836
• Nab3’s localization to a nuclear granule in response to nutrient deprivation is determined by its essential prion-like domain.
  Loya TJ, O’Rourke TW, Simke WC, Kelley JB, Reines D.
  PLoS One. 2018 Dec 17;13(12):e0209195. doi: 10.1371/journal.pone.0209195. eCollection 2018.
  PMID: 30557374
• Fluorescence-based quantification of nucleocytoplasmic transport.
  Kelley JB, Paschal BM.
  Methods. 2018 Nov 10. pii: S1046-2023(18)30123-3. doi: 10.1016/j.ymeth.2018.11.002. [Epub ahead of print]
  PMID: 30419335
• Unique Down to Our Microbes-Assessment of an Inquiry-Based Metagenomics Activity.
  Lentz TB, Ott LE, Robertson SD, Windsor SC, Kelley JB, Wollenberg MS, Dunn RR, Goller CC.
  J Microbiol Biol Educ. 2017 Jun 9;18(2). pii: 18.2.33. doi: 10.1128/jmbe.v18i2.1284. eCollection 2017.
  PMID: 28861131
• Venkatapurapu SP, Kelley JB (co-first author), Dixit G, Pena M, Errede B, Dohlman HG and Elston TC. The RGS protein Sst2 Regulates Receptor Dynamics during the Mating Response of Yeast  Mol Biol Cell 2015 Nov 11.
• Nagiec MJ, McCarter PC, Kelley JB, Dixit G, Elston TC, Dohlman HG. Signal inhibition by a dynamically-regulated pool of mono-phosphorylated MAPK. Mol Biol Cell. 2015 Jul 15.
• Kelley JB, Dixit G, Sheetz JB^#, Venkatapurapu SP, Elston TC, and Dohlman HG. RGS Proteins and Septins Cooperate to Promote Chemotropism by Regulating Polar Cap Mobility. Curr Biol. 2015 Feb 2.
• Dixit G, Kelley JB, Houser JR, Elston TC, and Dohlman HG. Cellular Noise Suppression by the Regulator of G Protein Signaling Sst2.  Mol Cell, 2014 July 3.
• Ni L, Llewellyn R, Kesler C, Kelley JB, Spencer A, Snow CJ, Shank L, and Paschal BM. Androgen Induces a Switch from Cytoplasmic Retention to Nuclear Import of the Androgen Receptor.  Mol Cell Biol. 2013 Oct 7.
• Paciorkowski AR, Weisenberg J, Kelley JB, Spencer A, Tuttle E , Ghoneim D, Thio LL, Christian SL, Dobyns WB, Paschal BM. Autosomal recessive mutations in nuclear transport factor KPNA7 are associated with infantile spasms, partial agenesis of the corpus callosum, and cerebellar vermis hypoplasia. Eur J Hum Genet. 2013 Sep 18.
• Kelley JB, Datta S, Snow CJ, Chatterjee M, Ni L, Spencer A, Yang CS, Cubeñas-Potts C, Matunis MJ, Paschal BM. The defective nuclear lamina in Hutchinson-Gilford progeria syndrome disrupts the nucleocytoplasmic Ran gradient and inhibits nuclear localization of Ubc9. Mol Cell Biol. 2011 Aug; 31(16):3378-95.
• Zhu M, Torres MP, Kelley JB, Dohlman HG, Wang Y. Pheromone- and RSP5-dependent ubiquitination of the G protein beta subunit Ste4 in yeast. J Biol Chem. 2011 Aug 5; 286(31):27147-55.
• Kelley JB, Talley AM^#, Spencer A, Gioeli D, Paschal BM. Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. BMC Cell Biol. 2010 Aug 11; 11:63.
• Shank LC, Kelley JB, Gioeli D, Yang CS, Spencer A, Allison LA, Paschal BM.  Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro. J Biol Chem. 2008 Apr 18; 283(16):10568-80.
• Kelley JB, and Paschal BM.  Hyperosmotic Stress Signaling to the Nucleus Disrupts the Ran Gradient and the Production of RanGTP. Mol. Biol. Cell 2007 18; 4365-4376
• Yang CS, Xin HW, Kelley JB, Spencer A, Brautigan DL, Paschal BM. Ligand Binding to the Androgen Receptor Induces Conformational Changes That Regulate Phosphatase Interactions. Mol. Cell. Biol. 2007 27; 3390-3404
• Racke FK, Wang D, Zaidi Z, Kelley J, Visvader J, Soh JW, Goldfarb AN. Potential Role for Protein Kinase C– in Regulating Megakaryocytic Lineage Commitment J. Biol. Chem. 2001 276; 522-528.

^# undergraduate co-author

Book Chapters:

• Paschal BM and Kelley JB. Nuclear Lamina. In: Encyclopedia of Biological Chemistry 2nd Ed. Elsevier; Feb 2013