New research from the Tilbury Laboratory investigating collagen remodeling in metastatic breast cancer has been accepted for publication in Scientific Reports, highlighting the continued impact of COBRE-supported research at the University of Maine. The study, “Targeting the D93 cryptic collagen epitope alters integrin α2β1-dependent cellular migration and collagen remodeling in metastatic breast cancer,” examines how […]
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New research from the Tilbury Laboratory highlights how advanced label-free optical imaging techniques can provide deeper insight into collagen remodeling in metastatic breast cancer and its role in tumor progression. Using Second Harmonic Generation (SHG) imaging and two-photon microscopy in 3D human breast cancer spheroid models, researchers investigated how breast cancer cells remodel collagen architecture […]
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Undergraduate Researchers Present Work at UMaine Student Symposium Undergraduate researchers mentored by COBRE-affiliated faculty presented their work at the University of Maine Student Symposium this spring, highlighting research across virology, inflammation, and infectious disease biology. Through hands-on laboratory experience, students are contributing to ongoing biomedical research while developing technical and analytical skills that support future […]
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2026 UMaine Student Symposium This spring, students mentored by COBRE-affiliated faculty presented research at the University of Maine Student Symposium. The posters represented a wide range of disciplines, including biomedical sciences, engineering, infectious disease research, zebrafish models, mitochondrial biology, and tissue engineering. The symposium highlighted the collaborative research environment at UMaine and the important role […]
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Emily Spaulding, Ph.D., a Maine INBRE project leader and assistant professor at the MDI Biological Laboratory, has received a $2.3 million, five-year Maximizing Investigators’ Research Award from the National Institutes of Health. The grant will support her research on how cells organize the nucleolus, a key internal structure responsible for producing ribosomes, the molecular machinery […]
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The University of Maine’s zebrafish research facility is gaining statewide attention for its growing impact on biomedical discovery, student research opportunities, and scientific collaboration. A recent feature in Bangor Daily News highlights how the lab is helping researchers better understand human health and disease through innovative studies using zebrafish models. Zebrafish are widely used in […]
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Understanding how the body repairs itself and why that ability declines with age is at the center of research led by Romain Madelaine, Ph.D., assistant professor at MDI Biological Laboratory. In a recent Q&A feature, Madelaine shares insights into how studying zebrafish regeneration may help scientists uncover new strategies to support human health. Madelaine’s research […]
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A year ago, we featured Jordan Miner, a UMaine Ph.D. candidate in biomedical engineering, recipient of the Janet Waldron Doctoral Research Fellowship. Jordan was co-advised by Drs. Karissa Tilbury, COBRE Pilot project leader, and Andre Khalil. Her research is focused on breast cancer. While working on the COBRE pilot project and as a fellowship recipient, […]
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Researchers at MDI Biological Laboratory have developed a novel transgenic zebrafish model that significantly accelerates the study of sarcopenia, the age-related loss of muscle mass and strength. The work, published in PLOS Genetics, introduces a powerful, experimentally controllable platform for investigating the molecular mechanisms driving muscle degeneration. Led by Roman Madelaine, Ph.D., the team engineered […]
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Samantha Barrick, assistant professor of biochemistry at UMaine, received a $231,000 Career Development Award from the American Heart Association to investigate how defects in force-sensing proteins impact the heart’s ability to pump blood. The three-year grant will support Barrick’s research as she measures the force generated by individual heart muscle cells with and without mutations […]
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