{"id":45162,"date":"2022-09-01T15:20:52","date_gmt":"2022-09-01T19:20:52","guid":{"rendered":"https:\/\/umaine.edu\/medicine\/?post_type=tribe_events&p=45162"},"modified":"2022-10-24T14:45:13","modified_gmt":"2022-10-24T18:45:13","slug":"title-tbd-3","status":"publish","type":"tribe_events","link":"https:\/\/umaine.edu\/medicine\/event\/title-tbd-3\/","title":{"rendered":"The Prophages of Pathogenic Mycobacteria and Their Role in Intrinsic Drug Resistance"},"content":{"rendered":"

Speaker: <\/strong>Sally D. Molloy, Ph.D.\u00a0Associate Professor of Genomics,\u00a0The University of Maine Honors College,\u00a0Department of Molecular and Biomedical Sciences<\/p>\n

About the seminar:<\/b> Mycobacterium abscessus is an emerging pathogen in cystic fibrosis patients with a\u00a0treatment success rate of only 45%, and is considered one of the most drug-resistant\u00a0mycobacteria. Resistant isolates commonly display increased expression of intrinsic\u00a0antibiotic resistance genes, making drug treatment challenging. The Molloy lab\u00a0recently demonstrated that integrated viral genomes, or prophages, increase\u00a0mycobacterial antibiotic resistance and expression of conserved mycobacterial\u00a0antibiotic resistance genes. Bacteria belonging to the M. chelonae-abscessus complex\u00a0are typically lysogens, meaning their genomes carry one or more prophages that have\u00a0the potential to regulate intrinsic antibiotic resistance. The goal of the Molloy lab is to\u00a0understand how prophages regulate mycobacterial antibiotic resistance and alter gene\u00a0expression in mycobacteria. We are specifically investigating how phage lifecycles\u00a0and phage-encoded toxin systems contribute to antibiotic resistance.<\/p>\n

About the speaker: <\/strong>Dr. Molloy is an Associate Professor of Genomics in the department of\u00a0Molecular and Biomedical Sciences and in the Honors College. She grew up in Maine\u00a0and received her BA in Biology and German at Colby College and her PhD in\u00a0Microbiology at the University of Maine. Dr. Molloy has an integrated teaching and\u00a0research program in which she guides undergraduate and graduate students in\u00a0bacteriophage research. She is the director of the UMaine SEA-PHAGES program, a\u00a0year-long research course designed to give first-year students authentic research\u00a0experiences in bacteriophage biology. Dr. Molloy\u2019s research program focuses on\u00a0interactions of prophages, integrated viral genomes, in pathogenic mycobacteria and\u00a0how these viruses impact mycobacterial gene expression, virulence and antibiotic\u00a0resistance.\u00a0Read more<\/a><\/p>\n

This event is free, but registration is required<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Speaker: Sally D. Molloy, Ph.D.\u00a0Associate Professor of Genomics,\u00a0The University of Maine Honors College,\u00a0Department of Molecular and Biomedical Sciences About the seminar: Mycobacterium abscessus is an emerging pathogen in cystic fibrosis […]<\/p>\n","protected":false},"author":1801,"featured_media":45488,"template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_tribe_events_status":"","_tribe_events_status_reason":"","_tribe_events_is_hybrid":"","_tribe_events_is_virtual":"","_tribe_events_virtual_video_source":"","_tribe_events_virtual_embed_video":"","_tribe_events_virtual_linked_button_text":"","_tribe_events_virtual_linked_button":"","_tribe_events_virtual_show_embed_at":"","_tribe_events_virtual_show_embed_to":[],"_tribe_events_virtual_show_on_event":"","_tribe_events_virtual_show_on_views":"","_tribe_events_virtual_url":"","footnotes":"","spc_primary_tribe_events_cat":0},"tags":[],"tribe_events_cat":[108],"class_list":["post-45162","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","tribe_events_cat-seminar-series","cat_seminar-series"],"taxonomy_info":{"tribe_events_cat":[{"value":108,"label":"Seminar Series"}]},"featured_image_src_large":["https:\/\/umaine.edu\/medicine\/wp-content\/uploads\/sites\/483\/2022\/09\/Undergraduate-Student-Highlight-Gerren-Welch-3-1024x683.png",1024,683,true],"author_info":{"display_name":"cferguson","author_link":"https:\/\/umaine.edu\/medicine\/author\/cferguson\/"},"comment_info":"","_links":{"self":[{"href":"https:\/\/umaine.edu\/medicine\/wp-json\/wp\/v2\/tribe_events\/45162","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/umaine.edu\/medicine\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/umaine.edu\/medicine\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/umaine.edu\/medicine\/wp-json\/wp\/v2\/users\/1801"}],"version-history":[{"count":8,"href":"https:\/\/umaine.edu\/medicine\/wp-json\/wp\/v2\/tribe_events\/45162\/revisions"}],"predecessor-version":[{"id":45514,"href":"https:\/\/umaine.edu\/medicine\/wp-json\/wp\/v2\/tribe_events\/45162\/revisions\/45514"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/umaine.edu\/medicine\/wp-json\/wp\/v2\/media\/45488"}],"wp:attachment":[{"href":"https:\/\/umaine.edu\/medicine\/wp-json\/wp\/v2\/media?parent=45162"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/umaine.edu\/medicine\/wp-json\/wp\/v2\/tags?post=45162"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/umaine.edu\/medicine\/wp-json\/wp\/v2\/tribe_events_cat?post=45162"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}