Randomized Controlled Trials of Antidepressants: Clinically and Scientifically Irrelevant David Cohen, Florida International University and David H. Jacobs, Pyrysys Psychology Group This contribution to the “antidepressant debate” (republished here from a 2007 article in the now-defunct journal, Debates in Neuroscience) focuses on the validity of randomized controlled trials. We argue that: (a) randomized controlled trials do