{"id":198,"date":"2016-02-12T11:55:15","date_gmt":"2016-02-12T16:55:15","guid":{"rendered":"https:\/\/umaine.edu\/howelllab\/?page_id=198"},"modified":"2023-02-07T14:56:59","modified_gmt":"2023-02-07T19:56:59","slug":"blood-and-protein-interactions-with-slippery-surfaces","status":"publish","type":"page","link":"https:\/\/umaine.edu\/howelllab\/research\/blood-and-protein-interactions-with-slippery-surfaces\/","title":{"rendered":"Blood and Protein Interactions with Slippery Surfaces"},"content":{"rendered":"<p><a href=\"https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood.png\"><img loading=\"lazy\" decoding=\"async\" class=\" size-medium wp-image-221 alignleft\" src=\"https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood-300x212.png\" alt=\"Susan blood\" width=\"300\" height=\"212\" srcset=\"https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood-300x212.png 300w, https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood-1024x723.png 1024w, https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood-105x74.png 105w, https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood-210x148.png 210w, https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood-317x224.png 317w, https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood-634x448.png 634w, https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood-423x299.png 423w, https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood-846x598.png 846w, https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood-1268x896.png 1268w, https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood-951x672.png 951w, https:\/\/umaine.edu\/howelllab\/wp-content\/uploads\/sites\/131\/2016\/02\/Susan-blood.png 1427w\" sizes=\"auto, (max-width: 320px) 85vw, (max-width: 768px) 67vw, (max-width: 1024px) 62vw,300px\" \/><\/a>The interactions of proteins with interfaces is fundamental to many questions in biology and medicine. In particular, the tendency of blood to coagulate on nearly every type of surface external to the body creates a number of problems in dialysis, surgery, and other areas which have yet to be solved. Recent work has shown that immobilized liquid layers can drastically reduce thrombus formation, even <em>in vivo. <\/em>We are working to further understand the basis of this as well as apply it both to coagulation on complex surfaces as well as protein adhesion control in general.<\/p>\n<p><strong>For more information, check out these publications:<\/strong><\/p>\n<p><a href=\"https:\/\/elifesciences.org\/articles\/75798\">Andersen, Marissa Jeme, et al. &#8220;Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections.&#8221;\u00a0<i>Elife<\/i>\u00a011 (2022): e75798.<\/a><\/p>\n<p><a href=\"https:\/\/www.researchgate.net\/publication\/308821187_Transparent_antifouling_material_for_improved_operative_field_visibility_in_endoscopy\">Sunny S, Cheng G, Daniel D, Lo P, Ochoa S, Howell C, Vogel N, Majid A, Aizenberg J (2016) Transparent antifouling material for improved operative field visibility in endoscopy. <em>Proceedings of the National Academy of Sciences<\/em>, 113,11676-11681.<\/a><\/p>\n<p><a href=\"https:\/\/www.researchgate.net\/publication\/266747512_A_bioinspired_omniphobic_surface_coating_on_medical_devices_prevents_thrombosis_and_biofouling\">Leslie D, Waterhouse A, Berthet J, Valentin T, Watters A, Jain A, Kim P, Hatton B, Nedder A, Mullen K, Super E, Howell C, Johnson C, Vu T, Rifai S, Hansen A, Aizenberg M, Super M, Aizenberg J, Ingber D (2014). A Bioinspired Surface Coating for Medical Devices that Prevents Thrombosis and Biofouling. <em>Nature Biotechnology<\/em>, 32, 1134-1140.<\/a><\/p>\n<p><a href=\"https:\/\/www.researchgate.net\/publication\/265211232_Lubricant-Infused_Nanoparticulate_Coatings_Assembled_by_Layer-by-Layer_Deposition\">Sunny S, Vogel N, Howell C, Vu T, Aizenberg J (2014), Lubricant-Infused Nanoparticulate Coatings Assembled by Layer-by-Layer Deposition. <em>Advanced Functional Materials<\/em>, 24, 6658-6667.<\/a><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The interactions of proteins with interfaces is fundamental to many questions in biology and medicine. In particular, the tendency of blood to coagulate on nearly every type of surface external to the body creates a number of problems in dialysis, surgery, and other areas which have yet to be solved. Recent work has shown that [&hellip;]<\/p>\n","protected":false},"author":343,"featured_media":0,"parent":12,"menu_order":0,"comment_status":"open","ping_status":"closed","template":"","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-198","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Blood and Protein Interactions with Slippery Surfaces - Howell Biointerface Lab - University of Maine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/umaine.edu\/howelllab\/research\/blood-and-protein-interactions-with-slippery-surfaces\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Blood and Protein Interactions with Slippery Surfaces - Howell Biointerface Lab - University of Maine\" \/>\n<meta property=\"og:description\" content=\"The interactions of proteins with interfaces is fundamental to many questions in biology and medicine. 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