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PRODID:-//Center for Biomedical Research Excellence (COBRE) - ECPv6.15.17.1//NONSGML v1.0//EN
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X-WR-CALNAME:Center for Biomedical Research Excellence (COBRE)
X-ORIGINAL-URL:https://umaine.edu/cobre
X-WR-CALDESC:Events for Center for Biomedical Research Excellence (COBRE)
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DTSTART;TZID=America/New_York:20241114T130000
DTEND;TZID=America/New_York:20241114T143000
DTSTAMP:20260417T214835
CREATED:20241108T181549Z
LAST-MODIFIED:20241108T182258Z
UID:10000018-1731589200-1731594600@umaine.edu
SUMMARY:Imaris Demo Workshop
DESCRIPTION:The COBRE Microscopy and Image Analysis Core invites you to an Imaris demo workshop: \nAbout the workshop:  Imaris is an interactive image analysis software that allows you to analyze 2D\, 3D and 4D microscopy data. The Microscopy and Image Analysis CORE offers a full Imaris Software Suite allowing you to analyze your data easily and efficiently. In this workshop\, we will introduce you to the basics of Imaris and cover the various analysis endpoints we can help you reach. From there we will go into a live demo and show you a number of workflows you can use to analyze your own data. We will cover how to use Imaris Spots\, Surfaces and Cells\, track objects over time\, and take a number of different measurements including colocalization. We will also show you how to take advantage of our new AI/ML tools. By the end of this workshop\, you will have a basic understanding of how to use Imaris to analyze your data and who to contact if you need analysis support. \nPlease email Zhengxin Ma at zhengxin.ma@maine.edu to register for the virtual event and join the workshop here. \nDr. Ma will also answer any questions you may have about the event or about the Microscopy and Image Analysis Core. \n  \nContact Information:\nZhengxin Ma\, PhD\nMIAC Facility Manager\nHitchner Hall\, Room 282\nPhone: 207-581-2802\nUniversity of Maine\, Orono\, ME 04469
URL:https://umaine.edu/cobre/event/imaris-demo-workshop/
LOCATION:https://teams.microsoft.com/l/meetup-join/19%3ameeting_ZTQwMzA0NWEtOWMxMS00NjY4LWEwMmQtZmMyZWZjZWY3ZWJm%40thread.v2/0?context=%7b%22Tid%22%3a%22a4b77b20-135f-4cf0-a136-750f879e4314%22%2c%22Oid%22%3a%22a9c7691d-6fe5-47db-adf8-32a6433053d1%22%7d
CATEGORIES:Research
ATTACH;FMTTYPE=image/png:https://umaine.edu/cobre/wp-content/uploads/sites/681/2024/11/Logo-Scope-UMaine_v2-e1731089150323.png
ORGANIZER;CN="Microscopy and Image Analysis Core":MAILTO:zhengxin.ma@maine.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241118T113000
DTEND;TZID=America/New_York:20241118T123000
DTSTAMP:20260417T214835
CREATED:20241113T155341Z
LAST-MODIFIED:20241113T155341Z
UID:10000019-1731929400-1731933000@umaine.edu
SUMMARY:Fluorescence Imaging with Bruker Technologies
DESCRIPTION:Discover the Latest Advances in Fluorescence Imaging! \nFree Lunch & Learn Workshop \nJoin us for a hands-on\, in-depth exploration of fluorescence imaging! \nDate: Monday\, November 18\nTime: 11:30 AM – 12:30 PM\nLocation: University of Maine – Ferland Hall\, Room 202 \nPlease contact Kris Schoepfer at kris.schoepfer@bruker.com with any questions. \n 
URL:https://umaine.edu/cobre/event/fluorescence-imaging-with-bruker-technologies/
LOCATION:202 Ferland\, 46 Beddington Rd\, Orono\, ME\, 04473\, United States
CATEGORIES:Education,Research
ATTACH;FMTTYPE=image/png:https://umaine.edu/cobre/wp-content/uploads/sites/681/2024/11/KRIS-FM-M-WS-FLYER-V3_K_Tilbury-1-e1731512109916.png
ORGANIZER;CN="Karissa Tilbury":MAILTO:karissa.tilbury@maine.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20241121T110000
DTEND;TZID=America/New_York:20241121T120000
DTSTAMP:20260417T214835
CREATED:20241106T175227Z
LAST-MODIFIED:20250423T160956Z
UID:10000017-1732186800-1732190400@umaine.edu
SUMMARY:Combating Antimicrobial Resistance
DESCRIPTION:Speaker: Scott S Walker\, PhD\, Sr. Principal Scientist Merck & Co.\, Inc. Rahway\, NJ\, USA \nAbout the speaker: Scott earned a B.S. in Microbiology from The University of Maine and a Ph.D. in Molecular Biology from the University of Connecticut Health Center. His graduate work focused on understanding the basic architecture of a eukaryotic nuclear origin of DNA replication. Following postdoctoral work on activated transcription in eukaryotes at The University of Massachusetts Medical Center\, Scott joined Schering-Plough\, Inc. in the antibacterial and antifungal drug discovery group where he continues in the Infectious Disease and Vaccine division of Merck & Co.\, Inc. (Rahway\, NJ USA). Throughout a 25+-year pharmaceutical career as a basic scientist and team leader\, his work has focused on antibacterial and antifungal compound discovery\, target identification/validation\, and lead prioritization and optimization. Scott is also an ardent educator having mentored many interns and HBCU students and lectured at several universities. \nAbout the seminar:  Antimicrobial resistance (AMR) is a real and growing threat to human and animal health worldwide that jeopardizes many of the advances in medicine made over the past 75+ years. Combatting AMR requires exploiting novel targets in bacteria with new compounds that are not subject to resistance commonly encountered in the healthcare setting. This presentation will introduce two essential pathways found in drug-resistant Gram-negative bacteria and describe the discovery\, characterization\, and optimization of novel antibacterial small molecule and peptide inhibitors of these critical processes. \nThe event is free to attend and will be held in Stodder Hall\, Room 57\, on the UMaine Orono campus.
URL:https://umaine.edu/cobre/event/combating-antimicrobial-resistance/
LOCATION:Stodder Hall\, Room 48
CATEGORIES:Education,News,Research
ATTACH;FMTTYPE=image/png:https://umaine.edu/cobre/wp-content/uploads/sites/681/2024/11/Walker-2-e1731595054704.png
ORGANIZER;CN="Institute of Medicine":MAILTO:umainemed@maine.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250113T170000
DTEND;TZID=America/New_York:20250113T180000
DTSTAMP:20260417T214835
CREATED:20241218T145112Z
LAST-MODIFIED:20241218T160752Z
UID:10000020-1736787600-1736791200@umaine.edu
SUMMARY:MDIBL Science Café: Unlocking the Secrets of Vision Restoration
DESCRIPTION:Ever wonder how a tiny fish can regenerate its damaged eyes? Join Dr. Romain Madelaine and his team at MDI Biological Laboratory for an exciting look into how zebrafish are revolutionizing our understanding of eye diseases like macular degeneration\, glaucoma\, and diabetic retinopathy. \nZebrafish have a superpower: the ability to regenerate damaged tissues—eyes included! Now\, Dr. Madelaine’s groundbreaking research is exploring how we can apply these remarkable healing mechanisms to humans. Could this lead to real treatments for vision loss? \nDon’t miss out on this journey into the future of vision science. Together\, we might just unlock the secrets to better sight for all. Register here. \nMDI Science Cafés\nOur MDI Science Cafés provide relaxed and fun forums in which to learn about the science that affects your life.
URL:https://umaine.edu/cobre/event/mdibl-science-cafe-unlocking-the-secrets-of-vision-restoration/
LOCATION:
CATEGORIES:Education,Research
ATTACH;FMTTYPE=image/jpeg:https://umaine.edu/cobre/wp-content/uploads/sites/681/2024/12/eye-fish-e1734531710506.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250407T110000
DTEND;TZID=America/New_York:20250407T110000
DTSTAMP:20260417T214835
CREATED:20250227T164831Z
LAST-MODIFIED:20250423T160916Z
UID:10000022-1744023600-1744023600@umaine.edu
SUMMARY:Advanced AI Based Phenotyping of the Laboratory Mouse (Maine INBRE Data Science Colloquium)
DESCRIPTION:Speaker:  Vivek Kumar\, Ph.D.\, Assistant Professor\, The Jackson Laboratory \nAbout the speaker:  \nDr. Kumar carried out undergraduate research at The University of Chicago with Dr. Bob Haselkorn. He received his PhD at UCSD working with Dr. Michael G. Rosenfeld and structurally and biochemically characterized transcriptional co-repressors. During his postdoctoral work\, Dr. Kumar trained with Dr. Joseph S. Takahashi at Northwestern and UT Southwestern and worked on functional genomics approaches to dissect the genetics of addiction. \nThe Kumar Lab consists of geneticists\, neuroscientists\, and computer scientists. We are passionate about discovering novel targets and models for mental illness through innovation at the confluence of computational\, genetic\, and genomic methods. Broadly\, we are interested in development of better animal models and animal phenotyping methods for human psychiatric illnesses. We use computer vision approaches to quantitate behavior and functional approaches to understand its underlying neuronal and genetic architecture. We have developed high-throughput computer vision based methods for ethologically relevant animal phenotyping. In functional genomics work\, we use QTL and mutagenesis approaches to discover novel pathway that can be targeted for addiction therapeutics. Our approaches are flexible and can be applied towards many psychiatric phenotypes. In sum\, we are a leading research group using genetics as its foundation\, and a combination of biochemistry\, physiology\, imaging\, and computer vision techniques to dissect complex behavior in mammals. \nVisit the Kumar Lab \nGuests attending in person may obtain a parking pass online by creating a guest account via the webportal:  (https://umaine.t2hosted.com/cmn/auth_guest.aspx) \nA Zoom option is available for participants who cannot attend in person.  Please use this registration link if you plan to attend virtually.
URL:https://umaine.edu/cobre/event/vivekkumar/
LOCATION:Wells Conference Center\, Room 1
CATEGORIES:Education,News,Research
ATTACH;FMTTYPE=image/png:https://umaine.edu/cobre/wp-content/uploads/sites/681/2025/02/Kumar-8-e1741870337382.png
ORGANIZER;CN="Institute of Medicine":MAILTO:umainemed@maine.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250417T110000
DTEND;TZID=America/New_York:20250417T120000
DTSTAMP:20260417T214835
CREATED:20250205T170249Z
LAST-MODIFIED:20250423T184731Z
UID:10000021-1744887600-1744891200@umaine.edu
SUMMARY:COBRE seminar: Loss of Smyd1 Leads to Sarcomere Disruption and Activates Hsf1-Driven Heat Shock Response in Fish Muscle
DESCRIPTION:Speaker: Shaojun (Jim) Du\, Ph.D.\, Professor of Biochemistry and Molecular Biology\, University of Maryland\, School of Medicine. \nAbout the speaker: Dr. Du holds a Ph.D. in molecular biology and biochemistry from the University of Toronto and completed postdoctoral training in developmental biology and genetics at the University of Washington. He began his academic career in 1997 at the University of Maryland Biotechnology Institute and became an Associate Professor in 2003. In 2010\, Dr. Du joined the University of Maryland Baltimore and now serves as a professor in the Department of Biochemistry and Molecular Biology at the University of Maryland School of Medicine. Learn more \nAbout the seminar: Muscle fibers contain large subcellular assemblies of myofibrils\, which are formed by repetitive structures called sarcomeres – the contractile units of muscle cells. Our previous studies have demonstrated that Smyd1 is essential for sarcomere formation in skeletal and cardiac muscles. Loss of Smyd1 results in a complete disruption of sarcomere organization and a dramatic reduction in myosin protein levels in zebrafish embryos. To investigate the molecular mechanisms of Smyd1 function\, we characterized gene expression changes in smyd1 knockdown and knockout zebrafish embryos using RNA sequencing (RNA-seq). The results showed that loss of Smyd1 function leads to a dramatic\, muscle-specific upregulation of heat shock gene (HSP) expression. The most highly upregulated genes encode cytosolic heat shock proteins involved in proteotoxic stress response.  To further investigate the heat shock response and its functional significance in muscle cells\, we generated heat shock factor 1 (hsf1) knockout zebrafish mutants and analyzed HSP gene expression and muscle phenotypes in hsf1-/-;smyd1b-/- double mutant embryos. The results showed that hsf1 knockout blocked hsp gene upregulation and exacerbated muscle defects in the double mutants. Moreover\, we demonstrated that Hsf1 is essential for zebrafish survival under heat shock conditions. Together\, these studies reveal a critical link between Smyd1 deficiency and Hsf1-activated heat shock response in regulating muscle protein homeostasis and myofibril assembly. Furthermore\, they demonstrate that Hsf1-mediated HSP gene upregulation is vital for the survival of zebrafish larvae under thermal stress conditions.
URL:https://umaine.edu/cobre/event/cobre-seminar-myofibril-assembly/
LOCATION:Norman Smith Hall 107
CATEGORIES:Education,Event,News,Research
ATTACH;FMTTYPE=image/jpeg:https://umaine.edu/cobre/wp-content/uploads/sites/681/2025/01/Du_Shaojun-e1736446950916.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250428T140000
DTEND;TZID=America/New_York:20250428T140000
DTSTAMP:20260417T214835
CREATED:20250422T201730Z
LAST-MODIFIED:20250507T161936Z
UID:10000024-1745848800-1745848800@umaine.edu
SUMMARY:From Yeast to Humans and Back: Uncovering Novel Mechanisms of Actin Filament Nucleation
DESCRIPTION:Speaker:  Bruce Goode\, PhD. Chair and Professor of Biology\, Brandeis University \nBiography: Bruce Goode serves as Chair and Professor of the Biology Department at Brandeis University. After growing up in California’s Bay Area\, he earned his B.S. and Ph.D. in Cell Biology from UC Santa Barbara\, studying the human microtubule-associated protein Tau with Stuart Feinstein\, followed by postdoctoral research on yeast cytoskeletal systems in David Drubin’s laboratory at UC Berkeley. Since establishing his lab at Brandeis in 2000\, where he received tenure in 2005 and full professorship in 2010\, Dr. Goode has led multidisciplinary research spanning yeast and mammalian systems\, investigating the molecular mechanisms that regulate actin filament assembly and turnover\, as well as the intricate coordination between actin and microtubule cytoskeletons during endocytosis\, intracellular transport\, cell motility\, and morphogenesis. His research employs biochemistry\, in vitro single molecule imaging\, genetics\, and live cell imaging approaches to elucidate these fundamental cellular processes. His scientific contributions have earned him scholar awards from the Pew Charitable Trust\, March of Dimes\, and American Cancer Society\, alongside an NIH Research Career Development Award. His leadership in the field has included chairing Gordon Research Conferences\, serving as Editor-in-Chief of Cytoskeleton (2009-2016)\, and currently serving as monitoring editor at The Journal of Cell Biology\, and member of the F1000 advisory board. \nLearn more \nSeminar title:  From Yeast to Humans and Back: Uncovering Novel Mechanisms of Actin Filament Nucleation \nAbout the seminar:  Our understanding of cytoskeletal dynamics has been revolutionized by discoveries in actin filament nucleation pathways. This seminar will trace our journey from the initial identification of formins as critical actin nucleation factors in yeast\, to their regulation by factors such as yeast Bud6\, which enhances formin-mediated nucleation. I will discuss how this foundational work in yeast revealed unexpected mechanistic parallels in the human tumor suppressor protein adenomatous polyposis coli (APC) and its role in cell migration\, creating a bridge between fungal and mammalian cytoskeletal regulation. The presentation will culminate with our more recent discovery of a novel ‘composite’ actin nucleation mechanism involving cooperative interactions between two proteins. Together\, this work highlights the diversity of mechanisms used in cells to nucleate actin network assembly\, and how studying the evolutionary conservation of cytoskeletal regulation offers insights across model systems. \nPlease join us for this in person event in Stodder Hall\, room 57.
URL:https://umaine.edu/cobre/event/from-yeast-to-humans-and-back-uncovering-novel-mechanisms-of-actin-filament-nucleation/
LOCATION:Stodder 57 UMaine Orono campus
CATEGORIES:Education,News,Research
ATTACH;FMTTYPE=image/png:https://umaine.edu/cobre/wp-content/uploads/sites/681/2025/04/Goode-1-e1745433056523.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/New_York:20250923T120000
DTEND;TZID=America/New_York:20250923T130000
DTSTAMP:20260417T214835
CREATED:20250922T183857Z
LAST-MODIFIED:20250922T192854Z
UID:10000030-1758628800-1758632400@umaine.edu
SUMMARY:CORE Lunch & Learn presents: Microscopy and Image Analysis Core
DESCRIPTION:Curious about fluorescence microscopy or how imaging can support your research? Join us for our Lunch & Learn where we’ll introduce the Microscopy and Image Analysis Core (MIAC). You’ll get an overview of the equipment we offer – like confocal and stereo microscopes – and learn how tools like Imaris software can help you analyze your images. We offer hands-on training and support. Whether you’re getting started or exploring new techniques\, this is a great chance to see what’s available and ask questions. Plus lunch is provided! \nMIAC Lunch and Learn Flyer
URL:https://umaine.edu/cobre/event/core-lunch-learn-presents-microscopy-and-image-analysis-core/
LOCATION:Hill Auditorium (165 ESRB / Barrows Hall)\, Barrows Hall\, Orono\, ME\, 04469\, United States
CATEGORIES:Education,News,Research
ATTACH;FMTTYPE=image/png:https://umaine.edu/cobre/wp-content/uploads/sites/681/2025/09/MIAC-event-e1758566483527.png
ORGANIZER;CN="Microscopy and Image Analysis Core":MAILTO:megan.tardif@maine.edu
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20251023
DTEND;VALUE=DATE:20251025
DTSTAMP:20260417T214835
CREATED:20250905T125044Z
LAST-MODIFIED:20250905T125044Z
UID:10000027-1761177600-1761350399@umaine.edu
SUMMARY:2025 UMaine COBRE Retreat
DESCRIPTION:The third UMaine COBRE Retreat will take place October 23-25\, 2025\, at the MDI Biological Laboratory in Bar Harbor\, Maine. This invite-only event gathers senior personnel\, project and core leaders\, mentors\, and advisory committee members for research updates\, group discussions\, and individualized feedback from the External Advisory Committee. Travel\, meals\, and accommodations will be provided. \n 
URL:https://umaine.edu/cobre/event/2025-umaine-cobre-retreat/
LOCATION:MDI Biological Laboratory\, 159 Old Bar Harbor Rd\, Bar Harbor\, ME
CATEGORIES:Event,News,Research
ATTACH;FMTTYPE=image/jpeg:https://umaine.edu/cobre/wp-content/uploads/sites/681/2025/09/mdibl-signage-e1757076589283.jpeg
END:VEVENT
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