{"id":98,"date":"2010-04-21T11:15:06","date_gmt":"2010-04-21T16:15:06","guid":{"rendered":"http:\/\/sites.umaine.edu\/newbiomed\/?page_id=98"},"modified":"2022-01-05T15:56:08","modified_gmt":"2022-01-05T20:56:08","slug":"robert-gundersen","status":"publish","type":"page","link":"https:\/\/umaine.edu\/biomed\/home\/faculty\/robert-gundersen\/","title":{"rendered":"Robert Gundersen, Ph.D."},"content":{"rendered":"<h2>Department Chair<\/h2>\n<p><b>Education:<br \/>\n<\/b>Ph.D. University of Texas-Austin 1983<br \/>\nB.S. University of Lowell 1979<b><br \/>\n<\/b><\/p>\n<p><b>CV: <\/b><a href=\"https:\/\/\/umaine.edu\/biomed\/resource\/cv-gundersen-robert\/\">Download CV<\/a><\/p>\n<p><strong>Email:<\/strong>\u00a0<a href=\"mailto:gundersn@maine.edu\">Send an Email<\/a><\/p>\n<p><b>Phone: \u00a0<\/b><a href=\"tel:207.581.2802\">207.581.2802<\/a><\/p>\n<p><b>Office: <\/b>282 Hitchner Hall<b><br \/>\n<\/b><\/p>\n<p><b>Mailing Address: \u00a0<\/b>5735 Hitchner Hall\u00a0Orono, ME\u00a0 04469-5735<\/p>\n<p><strong>Research interests<\/strong><\/p>\n<p>How do cells respond to extracellular stimuli? What are the components of a cell&#8217;s response system and how are these components regulated? Cell stimulus response systems are referred to as Signal Transduction Pathways. A common eukaryotic signal transduction pathway is the G protein-mediated pathway in which G proteins link cell surface receptors to the appropriate effector\u00a0(response) systems.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-100 alignright\" src=\"\/biomed\/wp-content\/uploads\/sites\/651\/2010\/04\/gundersenrsrch1.jpg\" alt=\"gundersen research\" width=\"200\" height=\"157\" srcset=\"https:\/\/umaine.edu\/biomed\/wp-content\/uploads\/sites\/651\/2010\/04\/gundersenrsrch1.jpg 200w, https:\/\/umaine.edu\/biomed\/wp-content\/uploads\/sites\/651\/2010\/04\/gundersenrsrch1-105x82.jpg 105w\" sizes=\"auto, (max-width: 320px) 85vw, (max-width: 768px) 67vw, (max-width: 1024px) 62vw,200px\" \/><\/p>\n<p>We use techniques in cell biology, biochemistry, and molecular biology to examine G protein-mediated signal transduction. The soil amoebae, <em>Dictyostelium<\/em> is employed and serves as a model system for examining the roles G proteins play in cell physiology.<\/p>\n<p>In\u00a0<em>Dictyostelium discoideum<\/em>, a single G protein a-subunit, Ga2, controls entry into the developmental phase of the cell&#8217;s life cycle. Ga2 regulates three different effector systems; guanylyl cyclase, adenylyl cyclase and phospholipase C. How activation of each effector occurs through Ga2 and how this translates into the developmental process is being examined. Present research aims to understand how covalent modification of Ga2 by phosphate, myristate and palmitate regulate Ga2 function.<\/p>\n<h3>Recent Publications<\/h3>\n<ul>\n<li>Alamer, S., Kageyama, Y., and Gundersen, R. (2018)\u00a0Localization of palmitoylated and activated G protein \u03b1-subunit in <em>Dictyostelium discoideum<\/em>.\u00a0 J. Cell. Biochem.\u00a0 \u00a0<span id=\"header-section-doi\" class=\"article-header__meta-info-label\">DOI:\u00a0<\/span><span class=\"article-header__meta-info-data\">10.1002\/jcb.26689<\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Department Chair Education: Ph.D. University of Texas-Austin 1983 B.S. University of Lowell 1979 CV: Download CV Email:\u00a0Send an Email Phone: \u00a0207.581.2802 Office: 282 Hitchner Hall Mailing Address: \u00a05735 Hitchner Hall\u00a0Orono, ME\u00a0 04469-5735 Research interests How do cells respond to extracellular stimuli? What are the components of a cell&#8217;s response system and how are these components [&hellip;]<\/p>\n","protected":false},"author":1691,"featured_media":99,"parent":75,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"templates\/page-withsidebar.php","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-98","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Robert Gundersen, Ph.D. - Molecular &amp; Biomedical Sciences - University of Maine<\/title>\n<meta name=\"description\" content=\"Interested in cellular signaling using the model organism, Dictyostelium.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/umaine.edu\/biomed\/home\/faculty\/robert-gundersen\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Robert Gundersen, Ph.D. - 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