Research in G protein-mediated Signal Transduction using Dictyostelium Robert E. Gundersen, Ph.D. Chair & Associate Professor Department of Molecular & Biomedical Sciences, University of Maine Guanine nucleotide-binding regulatory protein (G protein) signal transduction in eukaryotes; regulation of chemotaxis, cell differentiation and other cellular responses by G proteins in Dictyostelium discoideum. In Dictyostelium discoideum, a single G