The College of Natural Sciences, Forestry, and Agriculture has research facilities throughout the state that serve as centers of research and development and public outreach. In addition, the college also has has a large number of laboratories that provide services to researchers on and off-campus, public agencies, private organizations, or the public. A number of facilities are units of the Maine Agricultural and Forest Experiment Station.
- Aroostook Farm. A center for potato research in Presque Isle, Maine, Aroostook Farm is a research facility of the Maine Agricultural and Forest Experiment Station.
- Blueberry Hill Farm. A center for wild blueberry research in Jonesboro, Maine, Blueberry Hill Farm is a research facility of the Maine Agricultural and Forest Experiment Station.
- Highmoor Farm. A center for fruit and vegetable research in Monmouth, Maine, Highmoor Farm is a research facility of the Maine Agricultural and Forest Experiment Station.
- J. F. Witter Teaching and Research Center. The Witter Center includes two research farms near the UMaine campus: Witter Farm, a center for livestock research and animal science teaching, and Rogers Farm, a center for forage and crops research. The Witter Center is a research facility of the Maine Agricultural and Forest Experiment Station.
- Clapp Greenhouse and Lyle E. Littlefield Ornamentals Trial Garden. The greenhouses and trial garden are centers for horticultural research in Orono, Maine. These are research facilities of the Maine Agricultural and Forest Experiment Station.
- Darling Marine Center. The Darling Marine Center in Walpole, Maine, is the site of world-renowned marine research. It functions year round to support UMaine faculty and students, along with visiting investigators from across the country and around the world.
- Zebrafish Facility. The Zebrafish Facility is located in Hitchner Hall at the UMaine campus in Orono. The facility contains nearly 800 tanks, holding more than 30,000 zebrafish, which are used for cutting-edge genomics research.
- Penobscot Experimental Forest. The Penobscot Experimental Forest is a 4,200-acre forest located approximately 15 miles from the UMaine campus, which is used as a site for research on forest management. The Northern Research Station of the U. S. Forest Service also conducts long-term research on the property.
- Holt Research Forest. The Holt Research Forest is a 300-acre forest in Arrowsic, Maine. Research at the forest focuses on long-term changes in forest plant and animal populations and improving our understanding the effects of forest management.
- Dwight B. Demeritt Forest. The Dwight B. Demeritt forest includes more than 2,000 acres immediately adjacent to the UMaine campus. The forest is used for education, research, demonstration, and recreation.
- Analytical Laboratory and Maine Soil Testing Service. Provides analytical services to the public and research staff including analyses of soil, plant tissue, compost, manure, irrigation water, wood ash, fertilizers, organic residuals and other materials for nutrient content, organic matter, lead and other trace elements. Orono campus.
- University of Maine Animal Health Laboratory. Provides service to the veterinarians, livestock producers and pet owners of the Maine. Performs a variety of diagnostic, microbiological tests and necropsy services to help in the determination and control of the specific causes of animal health related problems. Orono campus.
- Dr. Matthew Highlands Pilot Plant. A state-of-the-art facility committed to helping food processors, entrepreneurs, farmers, researchers, and students in the food industry. The lab offers a variety of options for anyone seeking to expand product lines, create value-added foods, solve issues in current food products, and scale up recipes for commercial production. Orono campus.
- Food Technology–Process and Product Reviews. Provides process and product reviews to small businesses. Though initially created to serve the people of Maine, current recipients of this service also come from the neighboring states of Vermont and New Hampshire. Orono campus.
- Food Technology–Consumer Testing Center. Specializes in the sensory evaluation of foods. Located in the Dr. Matthew Highlands Pilot Plant on the Orono campus.
- Chemical Food Safety Laboratory. Specializes in the development and modification of GC, HPLC and EIA methods for the analysis of a wide range of natural and man-made chemicals in both food and environmental matrices. Laboratory personnel routinely develop assays specific to client needs. Orono campus.
- Sawyer Environmental Laboratory. A multidisciplinary facility for environmental research and education at the University of Maine. The facility supports research at the University of Maine, and federal, state, and local agencies, and private industry.
- DNA Sequencing Laboratory. Provides electrophoresis, sequencing, primer walking, fragment analysis. Orono campus.
- Electron Microscopy Laboratory. Offers the tools and technical expertise for research and training in microscopy with both light and electron microscopes. Orono campus.
- Stable Isotopes Laboratory. Specializes in the measurement and interpretation of the light stable isotopic ratios of environmentally relevant elements (hydrogen, carbon, nitrogen, oxygen, and sulfur). Housed in the Sawyer Environmental Research Center, the SIL is primarily a facility of the Climate Change Institute and serves the research needs of the Institute faculty, staff, graduate, and undergraduate students.